March 13 @ 11:00 AM – 12:00 PM
Dr. Karen Schindler
Professor
Rutgers University
“Determining the genetic contributions to aneuploidy in eggs”
Abstract: A healthy egg is essential for a successful pregnancy and full-term development. The chromosome content of the egg and sperm is an exquisitely important characteristic: a single extra or missing chromosome in the embryo typically leads to arrested development and miscarriage (i.e., spontaneous abortion or pregnancy loss). Such numerical chromosomal abnormalities, termed “aneuploidies,” are most often found in the egg; approximately 10-25% of eggs in reproductive-age individuals are aneuploid and are the leading genetic cause of early miscarriage. My talk will focus on our work that aims to understand the basic mechanisms that control chromosome segregation in eggs and to identify genetic mutations that lead to extreme egg aneuploidy in humans.
Host: Kathleen Leon Parada
Seminar will be held in person only.
Developmental & Cell Biology Seminar Series
Each quarter the Department of Developmental and Cell Biology hosts a weekly seminar. The purpose of these seminars is to enable experts from around the country to share their newest discoveries and ideas with our students and faculty. Seminars are held on Thursdays at 11:00 a.m., in Natural Sciences II room 4201.
For questions about this event, please contact Mayra Rubio at mrubio3@uci.edu.