April 3 @ 11:00 AM – 12:00 PM
Dr. Travis Thomson
Assistant Professor
University of Massachusetts
“Dueling Transposons Regulate Structural Synaptic Plasticity”
Abstract: Transposons are parasitic genome elements that can also serve as raw material for the evolution of new cellular functions. However, how retrotransposons are selected and domesticated by host organisms to modulate synaptic plasticity remains largely unknown. Here, we show that the Ty1 retrotransposon Copia forms virus-like capsids in vivo and transfers between cells. Copia is enriched at the Drosophila neuromuscular junction (NMJ) and transported across synapses, and disrupting its expression promotes both synapse development and structural synaptic plasticity. We show that proper synaptic plasticity is maintained in Drosophila by the balance of Copia and the Arc1 (activity-regulated cytoskeleton-associated protein) homolog. High-resolution cryogenic-electron microscopy imaging shows that the structure of the Copia capsid has a large capacity and pores like retroviruses but is distinct from domesticated capsids such as dArc1. Our results suggest a fully functional transposon mediates synaptic plasticity, possibly representing an early stage of domestication of a retrotransposon.
Host: Prof. Nick Baker
Seminar will be via Zoom
Meeting ID: 935 0482 6445
Passcode:754037
For questions about this event, please contact Mayra Rubio at mrubio3@uci.edu.