June 8, 2021 @ 7:00 AM – June 10, 2021 @ 4:00 PM
The Trisomy 21 Research Society Virtual Conference (T21RS 2021) will be held virtually from June 8 to 10, 2021 through the online platform EventsOnAir. All participants will have access by a user and a password to all sessions live from their computer, laptop or tablet.
Schedule: From 7:00am PST and 4:00pm CET
Duration: 4 hours approximately
| TUESDAY, JUNE 8 2021 Biomarkers and Neuropathology in Down syndrome | |
| STARTING TIME | SESSION |
|---|---|
| 4:00 pm CET / 7:00 am PST | WELCOME → Dr. Andre Strydom (UK), Dr. Jorge Busciglio (Chair USA) and Dr. Elizabeth Head (USA) |
| 4:15 pm CET / 7:15 am PST | T21RS GENERAL ASSEMBLY → Dr. Andre Strydom (UK) and Maria Martinez de Lagran Cabredo (Spain) |
| 5:00 pm CET / 8:00 am PST | Break |
| 5:20 pm CET / 8:20 am PST | PLENARY LECTURE → ABC-DS: Progress update and recent findings. |
| 6:05 pm CET / 9:05 am PST | Break |
| 6:25 pm CET / 9:25 am PST | SYMPOSIUM SESSION 1 → Molecular and cellular pathology in Down syndrome brain with aging: Neuropathological studies. → Tau cortical neuron expression profiling in demented and nondemented cases with Down Syndrome. → The role of innate immune and iron-related putative biomarker proteins in Alzheimer’s disease pathology in Down syndrome. → Lewy body pathology in Down syndrome brain post mortem. → Live discussion |
| 7:10 pm CET / 10:10 am PST | Break |
| 7:30 pm CET / 10:30 am PST | TRAINEE BLITZ |
| 8:15 pm CET / 11:15 am PST | CLOSE OF DAY 1 |
| WEDNESDAY, JUNE 9 2021 Behavioral and Clinical Studies in Down syndrome | |
| STARTING TIME | SESSION |
|---|---|
| 4:00 pm CET / 7:00 am PST | PLENARY LECTURE → The role of endo-lysosomal dysfunction in Down syndrome. |
| 4:45 pm CET / 7:45 am PST | Break |
| 5:05 pm CET / 8:05 am PST | SYMPOSIUM SESSION 2 → Neural correlates of intellectual disability. → Prefrontal-hippocampal neural dynamics as predictors of cognitive impairment and rescue in Down syndrome. → Electrocortical correlates of auditory processing in Down syndrome. → Multimodal MRI biomarkers for Alzheimer disease in Down syndrome. → Live discussion |
| 5:50 pm CET / 8:50 am PST | Break |
| 6:10 pm CET / 9:10 am PST | SCIENCE AND SOCIETY → PST Opening words. → Community Engaged Research: The Down Syndrome Community Informing Research. → Cultural program, drama piece. → Community engaged research: Centering self-advocates. → Research and the Voice of Caregivers – Results of Surveys and Focus Groups. → Longitudinal Data Outcomes on Adults with Down Syndrome and Dementia Supported in Group Homes. → Live discussion and closing remarks. |
| 7:10 pm CET / 10:10 am PST | Break |
| 7:30 pm CET / 10:30 am PST | SYMPOSIUM SESSION 3 → Down Syndrome Regression Disorder: Clinical Characteristics and Differential Diagnosis. → Are we underestimating the presence and treatment of mental illness in people with Down syndrome? → Regression in Down Syndrome: Multi-Center Data on Clinical Phenotypes. → Down Syndrome Regression Disorder: Neuroimmunologic Phenomenon and Responses to Immunomodulatory Therapy. → Live discussion |
| 8:15 pm CET / 11:15 am PST | CLOSE OF DAY 2 |
| THURSDAY, JUNE 10 2021 Inflammation in Down syndrome and Future Clinical Trials | |
| STARTING TIME | SESSION |
|---|---|
| 4:00 pm CET / 7:00 am PST | PLENARY LECTURE → Medical Vulnerability of Individuals with Down Syndrome to Severe COVID-19: Data from the Trisomy 21 Research Society COVID-19 Survey. |
| 4:45 pm CET / 7:45 am PST | Break |
| 5:05 pm CET / 8:05 am PST | SYMPOSIUM SESSION 4 → Brain and systemic inflammation in individuals with Down syndrome. → Neuroinflammation across the lifespan of individuals with Down syndrome. → Interferon hyperactivity in Down syndrome: causes, consequences, and therapeutic opportunities. → Systemic inflammation in children with Down syndrome. → Live discussion |
| 5:50 pm CET / 8:50 am PST | Break |
| 6:10 pm CET / 9:10 am PST | SYMPOSIUM SESSION 5 → Clinical trials to prevent Alzheimer’s disease in Down syndrome: state-of-the-art in clinical outcome measures. Chair: Dr. Andre Strydom (UK)→ CAMCOG-DS-II: development and validation of a clinical and research tool for diagnosis and neuropsychological assessment in people with Down syndrome with suspected dementia. Dr. Shahid Zaman (UK)→ The H21/ Life-DSR cognitive test battery – identification of a trial outcome measure for early intervention in Down syndrome and Alzheimer disease using longitudinal data across cohorts. Dr. Andy Aschenbrenner (USA) → Novel Endpoints in Down syndrome and Alzheimer disease: Using Goal Attainment Scaling to Measure Patient-Centered Outcomes. → Live discussion |
| 6:55 pm CET / 9:55 am PST | Break |
| 7:15 pm CET / 10:15 am PST | T21RS SOCIETY AWARDS → Annette Karmiloff-Smith and Michael Harpold Dissertation Award. T21RS SOCIETY AWARDS → TBN T21RS SOCIETY AWARDS – DATA BLITZ WINNERS → Dr. Elizabeth Head (USA) CLOSING → Dr. Andre Strydom (UK), Dr. Jorge Busciglio (USA) and Dr. Elizabeth Head (USA) |